Noyes, Harry and Githiori, John and Bradley, Janette E. and Kemp, Steve and Behnke, Jerzy M. (2015) Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome

Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1.

Resistance to infections with Heligmosomoides bakeri is associated with a significant quantitative trait locus (QTL-Hbnr1) on mouse chromosome 1 (MMU1). We exploited recombinant mice, with a segment of MMU1 from susceptible C57Bl/10 mice introgressed onto MMU1 in intermediate responder NOD mice (strains 1094 and 6109). BALB/c (intermediate responder) and C57Bl/6 mice (poor responder) were inclu...

Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice.

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hb...

Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections.

The intestinal nematode Heligmosomoides bakeri has undergone 2 name changes during the last 4 decades. Originally, the name conferred on the organism in the early 20th century was Nematospiroides dubius, but this was dropped in favour of Heligmosomoides polygyrus, and then more recently H. bakeri, to distinguish it from a closely related parasite commonly found in wood mice in Europe. H. bakeri...

Worm Survival Helminth-Driven Intestinal Pathology and Regulatory T Cells: A Role in the Control of

Wahid, F.N. and Behnke, Jerzy M. and Conway, David J. (1989) Factors affecting the efficacy of ivermectin against Heligmosomoides polygyrus (Nematospiroides

Wahid, F.N., Behnke, J.M. and Conway, D.J., 1989. Factors affecting the efficacy of ivermectin against Heligmosomoides polygyrus (Nematospiroides dubius ) in mice. Vet. Parasitol., 32: 325340. The efficacy of ivermectin against Heligmosomoides polygyrus was investigated in 5 mouse strains (CFLP, NIH, C57Bllo, B A L B / c and CBA ) using a variety of dose levels, and subcutaneous and oral admini...